Detroit Lions vs Buffalo Bills
Detroit Lions vs Buffalo Bills on Thursday, September 17, 2026 at Highmark Stadium. Full AMERICANFOOTBALL NFL odds, expert picks, sharp action and pre-game analysis.
Betting Odds
| Team | Moneyline | Spread | Total |
|---|---|---|---|
| Detroit Lions | +195 | +5.5 (-115) | O 54.5 (-118) |
| Buffalo Bills | -238 | -5.5 (-105) | U 54.5 (-102) |
Odds shown are the best available price across every top U.S. sportsbook tracked by Value Sports Network. Compare live lines, track line movement and shop the market on our full odds board.
About the Detroit Lions vs Buffalo Bills matchup
Value Sports Network covers every AMERICANFOOTBALL NFL matchup with live scoring, moneyline / spread / total odds from every top U.S. sportsbook, expert picks, sharp money indicators, public betting percentages, projections and a full box score with play-by-play. Bookmark this page for real-time updates through kickoff and beyond.
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